A condition affecting millions
Depression affects relationships, work, daily functioning and physical health. Psychotherapy and commonly used antidepressants help many people, but in some patients the response to treatment remains insufficient.
Modern clinical research is exploring investigational mechanisms of action and treatment models designed for people who do not respond sufficiently to standard care.
New medicines for depression
Traditional antidepressants often target serotonin or noradrenaline pathways. New investigational medicines may work through different neurotransmitter systems or combined therapeutic models.
These medicines are evaluated in structured clinical trials before they can be considered for routine use.
Why consider clinical trial participation?
- Study-related treatment, visits and procedures are covered within the protocol.
- Participants undergo detailed medical assessment and monitoring.
- Clinical trials can be considered by people whose symptoms persist despite standard treatment, if they meet protocol criteria.
Current depression studies at Promente
Update of 8 October 2026: Promente accepts inquiries for EMBRACE CYB003-003. Recruitment for OARS7 (JANSSEN 42847922MDD3003) at Promente is closed. KOASTAL-3 is completed and COMP 006 remains active but is not recruiting.